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Article

Mechanism of glucocorticoid regulation of the intestinal tight junction barrier.

American journal of physiology. Gastrointestinal and liver physiology - 1 Feb 2007

Boivin Michel A, Ye Dongmei, Kennedy John C, Al-Sadi Rana, Shepela Chris, Ma Thomas Y

Abstract excerpt

A defective intestinal epithelial tight junction (TJ) barrier has been proposed as an important pathogenic factor contributing to the intestinal inflammation of Crohn's disease. Glucocorticoids are first-line therapeutic agents for the treatment of moderate to severe Crohn's disease. Glucocorticoid treatment has been shown to induce retightening of the intestinal TJ barrier defect in Crohn's disease patients....

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Identifiers

PMID: 17068119
DOI: 10.1152/ajpgi.00252.2006
PMCID: PMC3724219

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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