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Article

Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion

9 Aug 2011

Abstract excerpt

BACKGROUND: Laminin-5 (Ln5), a heterotrimer composed of three chains (α3, β3, and γ2), is a major component of the basement membrane in most adult tissues. One of the chains, Ln5-γ2, is a marker of invasive tumours because it is frequently expressed as a monomer in malignant tumours. Recent studies from our laboratories detected higher levels of Ln5-γ2 expression in basal cell carcinoma (BCC) than in...

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PMID: 21829200
DOI: 10.1038/bjc.2011.283

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