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Article

Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5.

Journal of cell science - 1 Sept 2004

Sigle Randy O, Gil Susana G, Bhattacharya Mallar, Ryan Maureen C, Yang Tai-Mei, Brown Tod A, Boutaud Ariel, Miyashita Yuko, Olerud John, Carter William G

Abstract excerpt

In epidermal wounds, precursor laminin 5 (alpha3beta3gamma2) is deposited in the provisional basement membrane (PBM) before other BM components. Precursor laminin 5 contains G4/5 globular domains at the carboxyl terminus of the alpha3 chain. Here, the function of G4/5 was evaluated in deposition of laminin 5. Soluble laminin 5, secreted by keratinocytes in culture, is cleaved by an endogenous protease releasing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15316072
DOI: 10.1242/jcs.01310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5.PMID 15316072Read ↗

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