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Article

Biological function of laminin-5 and pathogenic impact of its deficiency.

European journal of cell biology - 1 Dec 2007

Schneider Holm, Mühle Christiane, Pacho Frederic

Abstract excerpt

The basement membrane glycoprotein laminin-5 is a key component of the anchoring complex connecting keratinocytes to the underlying dermis. It is secreted by keratinocytes as a cross-shaped heterotrimer of alpha3, beta3 and gamma2 chains and serves as a ligand of various transmembrane receptors, thereby regulating keratinocyte adhesion, motility and proliferation. In intact skin, laminin-5 provides essential...

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Identifiers

PMID: 17000025
DOI: 10.1016/j.ejcb.2006.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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