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Article

Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice.

PloS one - 1 Jan 2012

Adair-Kirk Tracy L, Griffin Gail L, Meyer Michelle J, Kelley Diane G, Miner Jeffrey H, Keene Douglas R, Marinkovich M Peter, Ruppert J Michael, Uitto Jouni, Senior Robert M

Abstract excerpt

Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent in many embryonic and adult tissues. In skin, laminin-332 is secreted by keratinocytes and is a key component of hemidesmosomes connecting the keratinocytes to the underlying dermis. In mice,...

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Source

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Identifiers

PMID: 23029085
DOI: 10.1371/journal.pone.0045546
PMCID: PMC3445496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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