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Article

Multiple Skin Squamous Cell Carcinomas in Junctional Epidermolysis Bullosa Due to Altered Laminin-332 Function.

International journal of molecular sciences - 20 Feb 2020

Fortugno Paola, Condorelli Angelo Giuseppe, Dellambra Elena, Guerra Liliana, Cianfarani Francesca, Tinaburri Lavinia, Proto Vittoria, De Luca Naomi, Passarelli Francesca, Ricci Francesca, Zambruno Giovanna, Castiglia Daniele

Abstract excerpt

Variably reduced expression of the basement membrane component laminin-332 (α3aβ3γ2) causes junctional epidermolysis bullosa generalized intermediate (JEB-GI), a skin fragility disorder with an increased susceptibility to squamous cell carcinoma (SCC) development in adulthood. Laminin-332 is highly expressed in several types of epithelial tumors and is central to signaling pathways that promote SCC tumorigenesis....

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Identifiers

PMID: 32093196
DOI: 10.3390/ijms21041426
PMCID: PMC7073068

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Multiple Skin Squamous Cell Carcinomas in Junctional Epidermolysis Bullosa Due to Altered Laminin-332 Function.PMID 32093196Read ↗

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