Article
Reduced expression of the epithelial adhesion ligand laminin 5 in the skin causes intradermal tissue separation.
The Journal of biological chemistry - 1 Jun 2001
Spirito F, Chavanas S, Prost-Squarcioni C, Pulkkinen L, Fraitag S, Bodemer C, Ortonne J P, Meneguzzi G
Abstract excerpt
Laminin 5, the major keratinocyte adhesion ligand, is found in the lamina lucida subregion of the epidermal basement membrane of the skin, where it colocalizes with the anchoring filaments. Mutations in the genes encoding laminin 5 cause junctional epidermolysis bullosa, an inherited skin blistering disease characterized by abnormal hemidesmosomes and cleavage of the lamina lucida leading to epidermal detachment....
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