Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects.

doi:10.1161/CIRCGENETICS.115.001302

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Article

Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects.

Circulation. Cardiovascular genetics - 1 Jun 2016

Drenos Fotios, Davey Smith George, Ala-Korpela Mika, Kettunen Johannes, Würtz Peter, Soininen Pasi, Kangas Antti J, Dale Caroline, Lawlor Debbie A, Gaunt Tom R, Casas Juan-Pablo, Timpson Nicholas J

Abstract excerpt

BACKGROUND: Plasma triglyceride levels have been implicated in atherosclerosis and coronary heart disease. Apolipoprotein C-III (APOC3) plays a key role in the hydrolysis of triglyceride-rich lipoproteins to remnant particles by lipoprotein lipase (LPL) and their uptake by the liver. A rare variant in APOC3(rs138326449) has been associated with triglyceride, very low-density lipoprotein, and high-density...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27114411
DOI: 10.1161/CIRCGENETICS.115.001302
PMCID: PMC4920206

Genes

APOC3
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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