Article
The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver.
Journal of hepatology - 1 Dec 2011
Valenti Luca, Nobili Valerio, Al-Serri Ahmad, Rametta Raffaela, Leathart Julian B S, Zappa Marco A, Dongiovanni Paola, Fracanzani Anna L, Alterio Arianna, Roviaro Giancarlo, Daly Ann K, Fargion Silvia, Day Christopher P
Abstract excerpt
BACKGROUND & AIMS: The T-455C and C-482T APOC3 promoter region polymorphisms (SNPs) have recently been reported to predispose to dyslipidemia, insulin resistance, and nonalcoholic fatty liver disease (NAFLD) in Indian subjects, but the association with liver damage has not been evaluated so far. The aim was to assess the association between APOC3 SNPs and liver damage in Caucasian patients. METHODS: We considered...
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