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Article

Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder.

Journal of pineal research - 1 May 2010

Gałecki Piotr, Szemraj Janusz, Bartosz Grzegorz, Bieńkiewicz Małgorzata, Gałecka Elzbieta, Florkowski Antoni, Lewiński Andrzej, Karbownik-Lewińska Małgorzata

Abstract excerpt

Depressive disorder (DD) is characterised by disturbances in blood melatonin concentration. It is well known that melatonin is involved in the control of circadian rhythms, sleep included. The use of melatonin and its analogues has been found to be effective in depression therapy. Melatonin synthesis is a multistage process, where the last stage is catalysed by acetylserotonin methyltransferase (ASMT), the...

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Source

Identifiers

PMID: 20433639
DOI: 10.1111/j.1600-079X.2010.00754.x

Genes

ASMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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