Article
Single nucleotide polymorphisms and mRNA expression for melatonin MT(2) receptor in depression.
Psychiatry research - 30 Oct 2011
Gałecka Elżbieta, Szemraj Janusz, Florkowski Antoni, Gałecki Piotr, Bieńkiewicz Małgorzata, Karbownik-Lewińska Małgorzata, Lewiński Andrzej
Abstract excerpt
Polymorphisms (rs 4753426 and rs 794837) and expression of the melatonin MT(2) receptor gene were evaluated in 181 patients with recurrent depressive disorder (rDD) and 149 healthy subjects of Polish origin. We found an increased risk for rDD in patients with the C allele and a decreased risk in patients with the T allele (rs4753426). Patients with the AT heterozygote (rs794837) had an increased mRNA level. The...
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