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Article

Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.

Human molecular genetics - 15 Sept 2012

Etain Bruno, Dumaine Anne, Bellivier Frank, Pagan Cécile, Francelle Laetitia, Goubran-Botros Hany, Moreno Sarah, Deshommes Jasmine, Moustafa Khaled, Le Dudal Katia, Mathieu Flavie, Henry Chantal, Kahn Jean-Pierre, Launay Jean-Marie, Mühleisen Thomas W, Cichon Sven, Bourgeron Thomas, Leboyer Marion, Jamain Stéphane

Abstract excerpt

Patients affected by bipolar disorder (BD) frequently report abnormalities in sleep/wake cycles. In addition, they showed abnormal oscillating melatonin secretion, a key regulator of circadian rhythms and sleep patterns. The acetylserotonin O-methyltransferase (ASMT) is a key enzyme of the melatonin biosynthesis and has recently been associated with psychiatric disorders such as autism spectrum disorders and...

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Source

Identifiers

PMID: 22694957
DOI: 10.1093/hmg/dds227

Genes

ASMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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