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Article

An ASMT variant associated with bipolar disorder influences sleep and circadian rhythms: a pilot study.

Genes, brain, and behavior - 1 Mar 2014

Geoffroy P A, Boudebesse C, Henrion A, Jamain S, Henry C, Leboyer M, Bellivier F, Etain B

Abstract excerpt

Patients with bipolar disorder (BD) experience persistent circadian rhythm and sleep abnormalities during periods of remission, and biological studies have shown that these patients have abnormal melatonin secretion profiles or reactivity to light. We previously reported the association with BD of a common polymorphism (rs4446909) of the promoter of the acetylserotonin O-methyltransferase (ASMT) gene, encoding...

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PMID: 24308489
DOI: 10.1111/gbb.12103

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ASMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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