Article
Design and characterization of stabilized derivatives of human CD4D12 and CD4D1.
Biochemistry - 20 Sept 2011
Saha Piyali, Barua Bipasha, Bhattacharyya Sanchari, Balamurali M M, Schief William R, Baker David, Varadarajan Raghavan
Abstract excerpt
CD4 is present on the surface of T-lymphocytes and is the primary cellular receptor for HIV-1. CD4 consists of a cytoplasmic tail, one transmembrane region, and four extracellular domains, D1-D4. A construct consisting of the first two domains of CD4 (CD4D12) is folded and binds gp120 with similar affinity as soluble 4-domain CD4 (sCD4). However, the first domain alone (CD4D1) was previously shown to be largely...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.