Article
MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency.
Retrovirology - 2 May 2012
Grupping Katrijn, Selhorst Philippe, Michiels Johan, Vereecken Katleen, Heyndrickx Leo, Kessler Pascal, Vanham Guido, Martin Loïc, Ariën Kevin K
Abstract excerpt
BACKGROUND: Binding of the viral envelope protein (Env), and particularly of its gp120 subunit, to the cellular CD4 receptor is the first essential step of the HIV-1 entry process. The CD4 binding site (CD4bs) of gp120, and especially a recessed cavity occupied by the CD4 Phe43 residue, are known to be highly conserved among the different circulating subtypes and therefore constitute particularly interesting...
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