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Article

Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation.

Bioorganic & medicinal chemistry letters - 1 May 2013

Zhao Lei, Hu Zhi-Wen, Tong Pei, Chen Yong-Xiang, Zhao Yu-Fen, Li Yan-Mei

Abstract excerpt

HIV entry is mediated by the envelope glycoproteins gp120 and gp41. The gp41 subunit contains several functional domains: the N-terminal heptad repeat (NHR) domains fold a triple stranded coiled-coil forming a meta-stable prefusion intermediate. C-terminal heptad repeat (CHR) subsequently folds onto the hydrophobic grooves of the NHR coiled-coil to form a stable 6-helix bundle, which juxtaposes the viral and...

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Identifiers

PMID: 23522564
DOI: 10.1016/j.bmcl.2013.02.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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