Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity.

doi:10.1128/JVI.65.9.4777-4785.1991

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Article

Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity.

Journal of virology - 1 Sept 1991

McKeating J, Balfe P, Clapham P, Weiss R A

Abstract excerpt

Variants of molecularly cloned human immunodeficiency virus type 1 (HIV-1) were analyzed following selection for the ability to replicate after exposure to soluble, recombinant CD4 protein (rCD4). Two variants, 4/1 and 16/2, show 8-fold and 16-fold reduced sensitivity to rCD4 neutralization yet remain as sensitive as the parental wild-type (wt) virus to neutralization by rCD4-immunoglobulin G (IgG) chimeric...

Topics

Amino Acid Sequence
CD4 Antigens
Cell Fusion
Cytopathogenic Effect, Viral
HIV Antibodies
HIV Envelope Protein gp120
HIV-1
Humans
In Vitro Techniques
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

Protein Binding

Recombinant Proteins

Solubility

Structure-Activity Relationship

Virus Replication

Source

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Identifiers

PMID: 1870202
DOI: 10.1128/JVI.65.9.4777-4785.1991
PMCID: PMC248935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1870202-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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