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Article

Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus.

Journal of medicinal chemistry - 4 Oct 2007

Xie Hui, Ng Danny, Savinov Sergey N, Dey Barna, Kwong Peter D, Wyatt Richard, Smith Amos B, Hendrickson Wayne A

Abstract excerpt

The first step in HIV infection is the binding of the envelope glycoprotein gp120 to the host cell receptor CD4. An interfacial "Phe43 cavity" in gp120, adjacent to residue Phe43 of gp120-bound CD4, has been suggested as a potential target for therapeutic intervention. We designed a CD4 mutant (D1D2F43C) for site-specific coupling of compounds for screening against the cavity. Altogether, 81 cysteine-reactive...

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Identifiers

PMID: 17803292
DOI: 10.1021/jm070564e
PMCID: PMC2532594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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