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Article

Haploinsufficiency by minute MutL homolog 1 promoter DNA methylation may represent unique phenotypes of microsatellite instability-gastric carcinogenesis.

PloS one - 1 Jan 2021

Harada Hiroki, Nie Yusuke, Araki Ippeita, Soeno Takafumi, Chuman Motohiro, Washio Marie, Sakuraya Mikiko, Ushiku Hideki, Niihara Masahiro, Hosoda Kei, Kumamoto Yusuke, Naitoh Takeshi, Sangai Takafumi, Hiki Naoki, Yamashita Keishi

Abstract excerpt

Promoter DNA methylation of MutL homolog 1 (MLH1) is considered to play a causative role in microsatellite instability (MSI) carcinogenesis in primary gastric cancer, and a high MSI status is associated with treatment sensitivity to human cancers. Nevertheless, clinicopathological analysis is defective for MLH1 methylation status in a quantitative manner. We newly developed quantitative methylation specific PCR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34936649
DOI: 10.1371/journal.pone.0260303
PMCID: PMC8694418

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