Article
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.
Nature genetics - 7 Aug 2011
Li Meng, Zhao Hong, Zhang Xiaosong, Wood Laura D, Anders Robert A, Choti Michael A, Pawlik Timothy M, Daniel Hubert D, Kannangai Rajesh, Offerhaus G Johan A, Velculescu Victor E, Wang Linfang, Zhou Shibin, Vogelstein Bert, Hruban Ralph H, Papadopoulos Nick, Cai Jianqiang, Torbenson Michael S, Kinzler Kenneth W
Abstract excerpt
Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC...
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