Article
Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis.
Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2020
Jiang Hao, Cao Hui-Jun, Ma Ning, Bao Wen-Dai, Wang Jing-Jing, Chen Tian-Wei, Zhang Er-Bin, Yuan Yan-Mei, Ni Qian-Zhi, Zhang Feng-Kun, Ding Xu-Fen, Zheng Qian-Wen, Wang Yi-Kang, Zhu Min, Wang Xiang, Feng Jing, Zhang Xue-Li, Cheng Shu-Qun, Ma Dan-Jun, Qiu Lin, Li Jing-Jing, Xie Dong
Abstract excerpt
Recurrence and metastasis remain the major obstacles to successful treatment of hepatocellular carcinoma (HCC). Chromatin remodeling factor ARID2 is commonly mutated in HCC, indicating its important role in cancer development. However, its role in HCC metastasis is largely elusive. In this study, we find that ARID2 expression is significantly decreased in metastatic HCC tissues, showing negative correlation with...
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