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Article

ARID2 modulates DNA damage response in human hepatocellular carcinoma cells.

Journal of hepatology - 1 May 2017

Oba Atsushi, Shimada Shu, Akiyama Yoshimitsu, Nishikawaji Taketo, Mogushi Kaoru, Ito Hiromitsu, Matsumura Satoshi, Aihara Arihiro, Mitsunori Yusuke, Ban Daisuke, Ochiai Takanori, Kudo Atsushi, Asahara Hiroshi, Kaida Atsushi, Miura Masahiko, Tanabe Minoru, Tanaka Shinji

Abstract excerpt

BACKGROUND & AIMS: Recent genomic studies have identified frequent mutations of AT-rich interactive domain 2 (ARID2) in hepatocellular carcinoma (HCC), but it is not still understood how ARID2 exhibits tumor suppressor activities. METHODS: We established the ARID2 knockout human HCC cell lines by using CRISPR/Cas9 system, and investigated the gene expression profiles and biological functions. RESULTS:...

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Source

Identifiers

PMID: 28238438
DOI: 10.1016/j.jhep.2016.12.026

Genes

ARID2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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