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Article

Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2.

The Journal of physiology - 15 Mar 2002

Gu Wenli, Schlichthörl Günter, Hirsch Jochen R, Engels Hartmut, Karschin Christine, Karschin Andreas, Derst Christian, Steinlein Ortrud K, Daut Jürgen

Abstract excerpt

Two novel alternatively spliced isoforms of the human two-pore-domain potassium channel TREK-2 were isolated from cDNA libraries of human kidney and fetal brain. The cDNAs of 2438 base pairs (bp) (TREK-2b) and 2559 bp (TREK-2c) encode proteins of 508 amino acids each. RT-PCR showed that TREK-2b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas TREK-2c is abundantly expressed...

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Identifiers

PMID: 11897838
DOI: 10.1113/jphysiol.2001.013432
PMCID: PMC2290188

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Source receipt: pubmed, retrieved 7 Sept 2026.

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