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HMGB1 contributes to SASH1 methylation to attenuate astrocyte adhesion

28 May 2019

Abstract excerpt

SAM and SH3 domain-containing 1 (SASH1), a scaffold protein, is regarded as a tumor suppressor. Recent studies have verified the decreased expression of SASH1 in many tumors. Our previous clinical investigation found that SASH1 was widely expressed in normal brain tissues but reduced or absent in glioma tissues. However, the functions of SASH1 in normal astrocytes and the reasons for the reductions in SASH1...

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PMID: 31138780
DOI: 10.1038/s41419-019-1645-7

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