Article
Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma.
Molecular cancer - 5 Aug 2013
Korah Reju, Healy James M, Kunstman John W, Fonseca Annabelle L, Ameri Amir H, Prasad Manju L, Carling Tobias
Abstract excerpt
BACKGROUND: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pathways, a clear genetic association or unique mutational link to the disease is still missing. Recent studies suggest a crucial role for epigenetic modifications in the genesis and/or progression...
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