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The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer

11 Sept 2018

Abstract excerpt

Background & Aims The tumor-suppressor sterile α motif– and Src-homology 3–domain containing 1 (SASH1) has clinical relevance in colorectal carcinoma and is associated specifically with metachronous metastasis. We sought to identify the molecular mechanisms linking decreased SASH1 expression with distant metastasis formation. Methods SASH1-deficient, SASH1-depleted, or SASH1-overexpressing HCT116 colon cancer...

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PMID: 30480076
DOI: 10.1016/j.jcmgh.2018.08.007

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