Article
Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.
Molecular and cellular biology - 1 Jun 2005
Yamaguchi Taihei, Sharma Prashant, Athanasiou Meropi, Kumar Amit, Yamada Satoru, Kuehn Michael R
Abstract excerpt
The covalent modification of proteins by the small ubiquitin-like protein SUMO has been implicated in the regulation of numerous biological processes, including nucleocytoplasmic transport, genomic stability, and gene transcription. Sumoylation occurs by a multienzyme process similar to ubiquitination and, in Saccharomyces cerevisiae, is reversed by desumoylating enzymes encoded by the Ulp1 and Smt4/Ulp2 genes....
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