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Article

Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.

Molecular and cellular biology - 1 Jun 2005

Yamaguchi Taihei, Sharma Prashant, Athanasiou Meropi, Kumar Amit, Yamada Satoru, Kuehn Michael R

Abstract excerpt

The covalent modification of proteins by the small ubiquitin-like protein SUMO has been implicated in the regulation of numerous biological processes, including nucleocytoplasmic transport, genomic stability, and gene transcription. Sumoylation occurs by a multienzyme process similar to ubiquitin...

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Share to Cysteine Endopeptidases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15923632
DOI: 10.1128/MCB.25.12.5171-5182.2005
PMCID: PMC1140580

Genes

SENP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15923632-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.PMID 15923632Read ↗

Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryo.Semantic proximity Read ↗

Sumoylation: a regulatory protein modification in health and disease.Semantic proximity Read ↗

SUMOylation and deSUMOylation at a glanceSemantic proximity Read ↗

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.Semantic proximity Read ↗

RNF4—A Paradigm for SUMOylation‐Mediated UbiquitinationSemantic proximity Read ↗

A SIM-ultaneous role for SUMO and ubiquitinSemantic proximity Read ↗

Sumo-1 function is dispensable in normal mouse development.Semantic proximity Read ↗

The SUMO system in Caenorhabditis elegans development.Semantic proximity Read ↗

Role of Desumoylation in the Development of Prostate CancerSemantic proximity Read ↗

Sumoylation in Development and Differentiation.Semantic proximity Read ↗

SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular FunctionSemantic proximity Read ↗

SUMO proteomics to decipher the SUMO‐modified proteome regulated by various diseasesSemantic proximity Read ↗

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