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Article

Sumo-1 function is dispensable in normal mouse development.

Molecular and cellular biology - 1 Sept 2008

Zhang Fu-Ping, Mikkonen Laura, Toppari Jorma, Palvimo Jorma J, Thesleff Irma, Jänne Olli A

Abstract excerpt

To elucidate SUMO-1 functions in vivo, we targeted by homologous recombination the last three exons of the murine Sumo-1 gene. Sumo-1 mRNA abundance was reduced to one-half in heterozygotes and was undetectable in Sumo-1(-/-) mice, and SUMO-1-conjugated RanGAP1 was detectable in wild-type mouse embryo fibroblasts (MEFs) but not in Sumo-1(-/-) MEFs, indicating that gene targeting yielded Sumo-1-null mice. Sumo-1...

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Identifiers

PMID: 18573887
DOI: 10.1128/MCB.00651-08
PMCID: PMC2519746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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