Article
Anti-atherogenic peptide Ep1.B derived from apolipoprotein E induces tolerogenic plasmacytoid dendritic cells.
Clinical and experimental immunology - 1 Sept 2014
Bellemore S M, Nikoopour E, Au B C Y, Krougly O, Lee-Chan E, Haeryfar S M, Singh B
Abstract excerpt
Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs ), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipoprotein E (ApoE)-derived self-peptide termed Ep1.B. We also showed that this C-terminal region...
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