The Proximal Promoter Region of the Zebrafish gsdf Gene Is Sufficient to Mimic the Spatio-Temporal Expression Pattern of the Endogenous Gene in Sertoli and Granulosa Cells1

Abstract excerpt

The gonadal soma-derived factor (GSDF) is a new member of the transforming growth factor beta (TGF-beta) superfamily that regulates the proliferation of the primordial germ cells (PGC) in developing embryos and spermatogonia in juvenile male trout. The gsdf transcripts are expressed in the somatic cells supporting germ cell development. In zebrafish, we show that GSDF is encoded by a single copy gene that...

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