Article
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
Scientific reports - 8 Jun 2016
He Man, Wang Min, Huang Ying, Peng Wenju, Zheng Zizheng, Xia Ningshao, Xu Jian, Tian Deying
Abstract excerpt
Hepatitis E virus (HEV) genotype 1 infection is common and can emerge as outbreaks in developing areas, thus posing a threat to public health. However, due to the absence of feasible animal models, the mechanism of HE pathogenesis remains obscure. The HEV pathogenic mechanism has been suggested to be mediated by the immune system and not by direct viral duplication. We firstly discovered that the open reading...
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