Article
Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors.
Cancer research - 15 Jan 2000
Cinti C, Claudio P P, Howard C M, Neri L M, Fu Y, Leoncini L, Tosi G M, Maraldi N M, Giordano A
Abstract excerpt
The prototypic tumor suppressor gene, the retinoblastoma gene (RB/ p105), is mutated in a variety of human tumors. However, to date, mutational data on retinoblastoma family members p107 and RB2/p130 in tumors is lacking. We studied the expression of pRb2/p130 by immunocytochemistry and Western blot analysis in a panel of human osteosarcoma and lymphoid cell lines. Only the lymphoid cell lines showed an abnormal...
Topics
- Amino Acid Substitution
- Burkitt Lymphoma
- Cell Nucleus
- Exons
- Female
- Frameshift Mutation
- Humans
- Immunohistochemistry
- Jurkat Cells
- Leukemia
- Lymphoma
- Male
- Mutagenesis, Site-Directed
- Mutation