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Article

Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors.

Cancer research - 15 Jan 2000

Cinti C, Claudio P P, Howard C M, Neri L M, Fu Y, Leoncini L, Tosi G M, Maraldi N M, Giordano A

Abstract excerpt

The prototypic tumor suppressor gene, the retinoblastoma gene (RB/ p105), is mutated in a variety of human tumors. However, to date, mutational data on retinoblastoma family members p107 and RB2/p130 in tumors is lacking. We studied the expression of pRb2/p130 by immunocytochemistry and Western blot analysis in a panel of human osteosarcoma and lymphoid cell lines. Only the lymphoid cell lines showed an abnormal...

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PMID: 10667591

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