Article
Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) study.
Atherosclerosis - 1 Dec 2003
Miller Eric A, Pankow James S, Millikan Robert C, Bray Molly S, Ballantyne Christie M, Bell Douglas A, Heiss Gerardo, Li Rongling
Abstract excerpt
Recent epidemiologic studies suggest that polymorphisms of glutathione-S-transferases M1 and T1 (GSTM1/GSTT1) modify the effects of cigarette smoking on risk of coronary heart disease (CHD). Since GSTs are able to detoxify numerous toxic compounds and products of oxidative stress, it is possible that GST genotypes may also modify the capacity of smoking to invoke a chronic inflammatory response. A cross-sectional...
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