Article
Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia.
AIDS (London, England) - 23 Oct 2011
Foxall Russell B, Albuquerque Adriana S, Soares Rui S, Baptista António P, Cavaleiro Rita, Tendeiro Rita, Gomes Perpétua, Victorino Rui M M, Sousa Ana E
Abstract excerpt
OBJECTIVE: The dynamics of CD4(+) regulatory T cells (Treg) during HIV-1 infection remains unclear. To further investigate Treg in this context, we characterized, for the first time, this population in HIV-2-positive individuals. Although both HIV infections are associated with hyperimmune activation and CD4(+) T-cell lymphopenia, most HIV-2-positive individuals display slower disease progression and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.