Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD8 naive T cell counts decrease progressively in HIV-infected adults.

1 May 1995

Abstract excerpt

We show here that CD8 naive T cells are depleted during the asymptomatic stage of HIV infection. Although overall CD8 T cell numbers are increased during this stage, the naive CD8 T cells are progressively lost and fall in parallel with overall CD4 T cell counts. In addition, we show that naive CD4 T cells are preferentially lost as total CD4 cell counts fall. These findings, presented here for adults, and in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV-related health complications and treatments
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7738173
DOI: 10.1172/jci117892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD8 naive T cell counts decrease progressively in HIV-infected adults.PMID 7738173Read ↗

Altered representation of naive and memory CD8 T cell subsets in HIV-infected children.Semantic proximity Read ↗

Harnessing CD8+ T Cells Under HIV Antiretroviral TherapySemantic proximity Read ↗

Impaired Phenotype and Function of T Follicular Helper Cells in HIV-1-Infected Children Receiving ART.Semantic proximity Read ↗

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and MortalitySemantic proximity Read ↗

HIV-specific CD8+ T cells and HIV eradicationSemantic proximity Read ↗

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies.Semantic proximity Read ↗

Persistence of an intact HIV reservoir in phenotypically naive T cells.Semantic proximity Read ↗

The role of naïve T-cells in HIV-1 pathogenesis: An emerging key playerSemantic proximity Read ↗

Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection.Semantic proximity Read ↗

Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life.Semantic proximity Read ↗

Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAARTSemantic proximity Read ↗

The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.