Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.

Developmental cell - 1 Feb 2003

Xi Rongwen, McGregor Jennifer R, Harrison Douglas A

Abstract excerpt

The Drosophila egg develops through closely coordinated activities of associated germline and somatic cells. An essential aspect of egg development is the differentiation of the somatic follicle cells into several distinct subpopulations with specific functions. Here we demonstrate that the graded activity of the Janus kinase (JAK) pathway, stimulated by the Unpaired ligand, patterns the anterior-posterior axis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Embryo, Nonmammalian
Share to Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 1

Share to Oogenesis

Share to Ovarian Follicle

Share to Protein-Tyrosine Kinases

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 12586061
DOI: 10.1016/s1534-5807(02)00412-4

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.PMID 12586061Read ↗

JAK signaling is somatically required for follicle cell differentiation in Drosophila.Semantic proximity Read ↗

Somatic control of germline sexual development is mediated by the JAK/STAT pathway.Semantic proximity Read ↗

Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.Semantic proximity Read ↗

JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in DrosophilaSemantic proximity Read ↗

The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis.Semantic proximity Read ↗

Regulation of somatic stem cell precursor fates and proliferation during <i>Drosophila melanogaster</i> pupal ovary development resembles the signaling framework for adult stem cell behaviorSemantic proximity Read ↗

Jak–STAT regulation of male germline stem cell establishment during Drosophila embryogenesisSemantic proximity Read ↗

Response to the dorsal anterior gradient of EGFR signaling in Drosophila oogenesis is prepatterned by earlier posterior EGFR activation.Semantic proximity Read ↗

Drosophila RalA is essential for the maintenance of Jak/Stat signalling in ovarian follicles.Semantic proximity Read ↗

Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand.Semantic proximity Read ↗

The Hippo pathway controls polar cell fate through Notch signaling during Drosophila oogenesis.Semantic proximity Read ↗

Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.