Article
Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2011
Nishioka Kinue, Nishida Motohiro, Ariyoshi Marina, Jian Zhong, Saiki Shota, Hirano Mayumi, Nakaya Michio, Sato Yoji, Kita Satomi, Iwamoto Takahiro, Hirano Katsuya, Inoue Ryuji, Kurose Hitoshi
Abstract excerpt
OBJECTIVE: The goal of this study was to determine whether inhibition of transient receptor potential canonical (TRPC) channels underlies attenuation of angiotensin II (Ang II)-induced vasoconstriction by phosphodiesterase (PDE) 3 inhibition. METHODS AND RESULTS: Pretreatment of rat thoracic aorta with cilostazol, a selective PDE3 inhibitor, suppressed vasoconstriction induced by Ang II but not that induced by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.