Molecular study of mechanisms of action of cilostazol on certain families of phosphodiesterases

Abstract excerpt

OBJECTIVE: The purpose of the study was to examine the effect of cilostazol on isoforms of targets of phosphodiesterase 3 and phosphodiesterase 5 by means of molecular modeling. MATERIAL AND METHODS: kcal · mol 1 · K 1) and T is the temperature (298.15 К). RESULTS: Cilostazol possesses higher affinity to isoform of PDE3A (Ki=54 nM) as compared with PDE3B (Ki=1.13 μM) based on the findings of the performed...

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