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Article

MAP-2e, a Novel MAP-2 Isoform, Is Expressed in Gliomas and Delineates Tumor Architecture and Patterns of Infiltration

1 May 2002

Abstract excerpt

The MAP-2 isoform containing exon 13 (MAP-2e) is expressed in human fetal development as early as 15 gestational weeks and parallels oligodendrocyte maturation. MAP-2e is down-regulated following myelination and is expressed in few cells in the adult central nervous system (CNS). To determine whether CNS tumors express MAP-2e, we screened 122 archival, paraffin-embedded adult and pediatric tumors of the CNS and...

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PMID: 12025943
DOI: 10.1093/jnen/61.5.403

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