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Article

PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma

27 Jul 2011

Abstract excerpt

Alterations of the cell cycle checkpoint frequently occur during hepatocarcinogenesis. Dysregulation of the phosphatidylinositol-3-kinases (PI3K) signaling pathway is believed to exert a potential oncogenic effect in hepatocellular carcinoma (HCC), ultimately promoting tumor cell proliferation. However, the impact of PI3K on cell cycle regulation remains unclear. We used a combined loss- and gain-of-function...

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PMID: 21796621
DOI: 10.1002/ijc.26319

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