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Article

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.

Human molecular genetics - 1 Nov 2009

Alegre-Abarrategui Javier, Christian Helen, Lufino Michele M P, Mutihac Ruxandra, Venda Lara Lourenço, Ansorge Olaf, Wade-Martins Richard

Abstract excerpt

Leucine rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD) although LRRK2 function remains unclear. We report a new role for LRRK2 in regulating autophagy and describe the recruitment of LRRK2 to the endosomal-autophagic pathway and specific membrane subdomains. Using a novel human genomic reporter cellular model, we found LRRK2 to locate to membrane microdomains...

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Identifiers

PMID: 19640926
DOI: 10.1093/hmg/ddp346
PMCID: PMC2758136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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