Article
Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins.
Traffic (Copenhagen, Denmark) - 1 Aug 2009
Tournaviti Stella, Pietro Enrica San, Terjung Stefan, Schafmeier Tobias, Wegehingel Sabine, Ritzerfeld Julia, Schulz Juliane, Smith Deborah F, Pepperkok Rainer, Nickel Walter
Abstract excerpt
Acylated SH4 domains represent N-terminal targeting signals that anchor peripheral membrane proteins such as Src kinases in the inner leaflet of plasma membranes. Here we provide evidence for a novel regulatory mechanism that may control the levels of SH4 proteins being associated with plasma membranes. Using a fusion protein of the SH4 domain of Leishmania HASPB and GFP as a model system, we demonstrate that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.