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Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53

3 Mar 2017

Abstract excerpt

In response to ionizing radiation (IR), cells activate a DNA damage response (DDR) pathway to re-program gene expression. Previous studies using total cellular RNA analyses have shown that the stress kinase ATM and the transcription factor p53 are integral components required for induction of IR-induced gene expression. These studies did not distinguish between changes in RNA synthesis and RNA turnover and did...

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PMID: 28256581
DOI: 10.1038/srep43598

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