Article
Mutations in 16S rRNA that suppress cold-sensitive initiation factor 1 affect ribosomal subunit association.
The FEBS journal - 1 Sept 2011
Belotserkovsky Jaroslav M, Dabbs Eric R, Isaksson Leif A
Abstract excerpt
A mutation in the infA gene encoding initiation factor 1 (IF1) gives rise to a cold-sensitive phenotype. An Escherichia coli strain with this mutation was used as a tool to select for second-site suppressors that compensate for the cold sensitivity and map specifically to rRNA. Several suppressor mutants with altered 16S rRNA that partially restore growth of an IF1 mutant strain in the cold were isolated and...
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