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Article

Suppression of a cold-sensitive mutant initiation factor 1 by alterations in the 23S rRNA maturation region.

The FEBS journal - 1 May 2011

Belotserkovsky Jaroslav M, Isak Georgina I, Isaksson Leif A

Abstract excerpt

Genetic selection has been used to isolate second-site suppressors of a defective cold-sensitive initiation factor I (IF1) R69L mutant of Escherichia coli. The suppressor mutants specifically map to a single rRNA operon on a plasmid in a strain with all chromosomal rRNA operons deleted. Here, we describe a set of suppressor mutations that are located in the processing stem of precursor 23S rRNA. These mutations...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21418143
DOI: 10.1111/j.1742-4658.2011.08099.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Suppression of a cold-sensitive mutant initiation factor 1 by alterations in the 23S rRNA maturation region.PMID 21418143Read ↗

Mutations in 16S rRNA that suppress cold-sensitive initiation factor 1 affect ribosomal subunit association.Semantic proximity Read ↗

Temperature sensitivity caused by mutant release factor 1 is suppressed by mutations that affect 16S rRNA maturation.Semantic proximity Read ↗

Mutations at three sites in the Escherichia coli 23S ribosomal RNA binding region for protein L11 cause UGA-specific suppression and conditional lethality.Semantic proximity Read ↗

Translation initiation region dependency of translation initiation in Escherichia coli by IF1 and kasugamycin.Semantic proximity Read ↗

Control of translation initiation involves a factor-induced rearrangement of helix 44 of 16S ribosomal RNA.Semantic proximity Read ↗

The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance.Semantic proximity Read ↗

Interaction of translation initiation factor IF1 with the E. coli ribosomal A site.Semantic proximity Read ↗

Intragenic suppressors of temperature-sensitive rne mutations lead to the dissociation of RNase E activity on mRNA and tRNA substrates in Escherichia coli.Semantic proximity Read ↗

srd1, a Saccharomyces cerevisiae suppressor of the temperature-sensitive pre-rRNA processing defect of rrp1-1.Semantic proximity Read ↗

Selection for intragenic suppressors of lethal 23S rRNA mutations in Escherichia coli identifies residues important for ribosome assembly and function.Semantic proximity Read ↗

Suppression of a cold-sensitive mutation in 16S rRNA by overexpression of a novel ribosome-binding factor, RbfA.Semantic proximity Read ↗

Roles of helix H69 of 23S rRNA in translation initiation.Semantic proximity Read ↗

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