Article
Array-based DNA methylation profiling in acute myeloid leukaemia.
British journal of haematology - 1 Oct 2011
Wilop Stefan, Fernandez Agustín F, Jost Edgar, Herman James G, Brümmendorf Tim H, Esteller Manel, Galm Oliver
Abstract excerpt
Methylation in the promoter region of many genes is involved in regulating gene expression patterns. Using the Illumina GoldenGate© methylation assay, we examined the methylation status of 1505 CpG-sites from 807 genes in 32 samples from patients with acute myeloid leukaemia (AML) at diagnosis, nine at relapse and 15 normal controls and performed additional pyrosequencing and semiquantitative methylation specific...
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