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Article

Regulation of Interferon Gamma Signaling by Suppressors of Cytokine Signaling and Regulatory T Cells

1 Jan 2013

Abstract excerpt

Regulatory T cells (Tregs) play an indispensable role in the prevention of autoimmune disease, as interferon gamma (IFNγ) mediated, lethal auto-immunity occurs (in both mice and humans) in their absence. In addition, Tregs have been implicated in preventing the onset of autoimmune and auto-inflammatory conditions associated with aberrant IFNγ signaling such as type 1 diabetes, lupus, and lipopolysaccharide (LPS)...

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Identifiers

PMID: 24391643
DOI: 10.3389/fimmu.2013.00469

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