Article
Partial rescue of NT-3 null mutant phenotype by a PDGF-β regulated transgene.
Neuroscience letters - 1 Sept 2011
Barski Jarosław J, Helbig Christian, Meyer Michael
Abstract excerpt
The phenotype of neurotrophin-3 (NT-3) null mutant mice is characterized by sensory ataxia and early postnatal death. Previous analysis revealed a severe depletion of peripheral sensory, sympathetic and parasympathetic neurons. Most of the deficits are established early during embryonic development. Whereas absence of proprioceptive afferents can explain the sensory ataxia, the reasons for early postnatal death...
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