Article
Pax-3 regulates neurogenesis in neural crest-derived precursor cells.
Journal of neuroscience research - 1 Jun 1999
Koblar S A, Murphy M, Barrett G L, Underhill A, Gros P, Bartlett P F
Abstract excerpt
The peripheral nervous system consists of multiple neural lineages derived from the neural crest (NC). Pax-3 is expressed in the NC and when mutated in the splotch mouse (Sp) results in the loss of derivatives from this precursor cell population. We have investigated the role of Pax-3 in regulating the generation of neurons from NC-derived precursor cells in vitro. Pax-3 mRNA in NC cultures is initially expressed...
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