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Article

Investigation of amygdala volume in men with the fragile X premutation.

Brain imaging and behavior - 1 Dec 2011

Selmeczy Diana, Koldewyn Kami, Wang John M, Lee Aaron, Harvey Danielle, Hessl David R, Tassone Flora, Adams Patrick, Hagerman Randi J, Hagerman Paul J, Rivera Susan M

Abstract excerpt

Premutation fragile X carriers have a CGG repeat expansion (55 to 200 repeats) in the promoter region of the fragile X mental retardation 1 (FMR1) gene. Amygdala dysfunction has been observed in premutation symptomatology, and recent research has suggested the amygdala as an area susceptible to the molecular effects of the premutation. The current study utilizes structural magnetic resonance imaging (MRI) to...

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Source

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Identifiers

PMID: 21786216
DOI: 10.1007/s11682-011-9132-5
PMCID: PMC3982607

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Investigation of amygdala volume in men with the fragile X premutation.PMID 21786216Read ↗

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Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X premutation.Semantic proximity Read ↗

Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation.Semantic proximity Read ↗

Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers.Semantic proximity Read ↗

The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy.Semantic proximity Read ↗

Investigation of phenotypes associated with mood and anxiety among male and female fragile X premutation carriers.Semantic proximity Read ↗

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Brain structure and intragenic DNA methylation are correlated, and predict executive dysfunction in fragile X premutation females.Semantic proximity Read ↗

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